This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for IP6K1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IP6K1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IP6K1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,539,369–49,540,584 | 246.6 kb | Distal (>10kb) Multiome | 628 | |
| chr3:49,553,618–49,555,244 | 232.1 kb | Distal (>10kb) Multiome | 710 | |
| chr3:49,718,116–49,720,106 | 66.9 kb | Distal (>10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 62.5 kb | Distal (>10kb) Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 76 bp | At TSS Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 16.3 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 70.1 kb | Distal (>10kb) Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 83.4 kb | Distal (>10kb) Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 117.4 kb | Distal (>10kb) Multiome | 415 | |
| chr3:49,929,290–49,930,212 | 143.2 kb | Distal (>10kb) Multiome | 799 | |
| chr3:49,939,635–49,940,747 | 153.5 kb | Distal (>10kb) Multiome | 949 |
Genomic view of the IP6K1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.