This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for INVS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INVS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INVS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:99,819,265–99,820,671 | 279.3 kb | Distal (>10kb) Multiome | 934 | |
| chr9:99,821,209–99,823,110 | 277.5 kb | Distal (>10kb) Multiome | 759 | |
| chr9:99,823,697–99,825,101 | 274.5 kb | Distal (>10kb) Multiome | 396 | |
| chr9:99,828,488–99,829,180 | 270.4 kb | Distal (>10kb) Multiome | 184 | |
| chr9:99,834,356–99,835,065 | 264.6 kb | Distal (>10kb) Multiome | 66 | |
| chr9:99,906,186–99,907,530 | 192.5 kb | Distal (>10kb) Multiome | 862 | |
| chr9:100,098,013–100,099,995 | 1.2 kb | Proximal (<10kb) Multiome | 884 | |
| chr9:100,352,182–100,353,419 | 253.7 kb | Distal (>10kb) Multiome | 937 |
Genomic view of the INVS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.