This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for INTS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:94,553,030–94,554,248 | 269.7 kb | Distal (>10kb) Multiome | 938 | |
| chr8:94,605,142–94,605,744 | 217.8 kb | Distal (>10kb) Multiome | 82 | |
| chr8:94,638,867–94,642,864 | 184.0 kb | Distal (>10kb) Multiome | 705 | |
| chr8:94,719,362–94,720,432 | 103.4 kb | Distal (>10kb) Multiome | 1182 | |
| chr8:94,813,351–94,813,687 | 9.6 kb | Proximal (<10kb) | 117 | |
| chr8:94,822,329–94,823,941 | 68 bp | At TSS Multiome | 818 | |
| chr8:94,894,252–94,897,051 | 72.2 kb | Distal (>10kb) Multiome | 927 | |
| chr8:94,948,413–94,950,514 | 126.2 kb | Distal (>10kb) Multiome | 850 | |
| chr8:95,024,342–95,025,424 | 201.7 kb | Distal (>10kb) Multiome | 980 |
Genomic view of the INTS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.