Predicted to act upstream of or within brain development; eye development; and mRNA splicing, via spliceosome. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for INTS15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,348,284–6,349,527 | 241.0 kb | Distal (>10kb) Multiome | 787 | |
| chr7:6,374,107–6,375,074 | 215.6 kb | Distal (>10kb) Multiome | 778 | |
| chr7:6,447,046–6,448,661 | 142.0 kb | Distal (>10kb) Multiome | 944 | |
| chr7:6,483,337–6,484,560 | 105.8 kb | Distal (>10kb) Multiome | 748 | |
| chr7:6,502,814–6,505,187 | 85.9 kb | Distal (>10kb) Multiome | 573 | |
| chr7:6,516,399–6,516,954 | 73.4 kb | Distal (>10kb) Multiome | 245 | |
| chr7:6,526,260–6,527,132 | 63.3 kb | Distal (>10kb) Multiome | 313 | |
| chr7:6,530,620–6,531,774 | 58.8 kb | Distal (>10kb) Multiome | 296 | |
| chr7:6,536,237–6,537,265 | 53.1 kb | Distal (>10kb) Multiome | 223 | |
| chr7:6,577,282–6,577,787 | 12.5 kb | Distal (>10kb) Multiome | 840 | |
| chr7:6,589,551–6,590,781 | 10 bp | At TSS Multiome | 802 | |
| chr7:6,614,875–6,616,376 | 25.4 kb | Distal (>10kb) Multiome | 610 | |
| chr7:6,640,237–6,641,084 | 50.6 kb | Distal (>10kb) Multiome | 238 | |
| chr7:6,663,809–6,664,686 | 74.0 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,706,296–6,707,347 | 116.9 kb | Distal (>10kb) Multiome | 718 | |
| chr7:6,729,225–6,730,453 | 139.7 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the INTS15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.