Predicted to be involved in snRNA 3'-end processing. Located in cytoplasm. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for INTS14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:65,355,116–65,356,095 | 255.6 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 233.2 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 225.5 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 209.8 kb | Distal (>10kb) Multiome | 406 | |
| chr15:65,414,873–65,415,582 | 195.9 kb | Distal (>10kb) Multiome | 333 | |
| chr15:65,421,061–65,422,050 | 189.7 kb | Distal (>10kb) Multiome | 457 | |
| chr15:65,422,462–65,423,579 | 188.1 kb | Distal (>10kb) Multiome | 450 | |
| chr15:65,517,110–65,517,892 | 93.6 kb | Distal (>10kb) Multiome | 1031 | |
| chr15:65,521,411–65,521,886 | 89.6 kb | Distal (>10kb) Multiome | 35 | |
| chr15:65,530,109–65,531,265 | 80.7 kb | Distal (>10kb) Multiome | 922 | |
| chr15:65,610,849–65,611,766 | 45 bp | At TSS Multiome | 1108 | |
| chr15:65,612,004–65,612,360 | 781 bp | At TSS | 105 | |
| chr15:65,791,540–65,792,954 | 181.1 kb | Distal (>10kb) Multiome | 949 | |
| chr15:65,832,500–65,833,207 | 221.7 kb | Distal (>10kb) Multiome HiCAR | 923 | |
| chr15:65,868,825–65,870,066 | 258.1 kb | Distal (>10kb) Multiome HiCAR | 1036 |
Genomic view of the INTS14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.