INTS11

integrator complex subunit 11 | CPSF73L, FLJ20542, INT11, RC-68, CPSF3L

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Member of: DE-1

Biological processes 28 terms

INTAC complex (GO:0160232)RNA endonuclease activity (GO:0004521)RNA endonuclease activity (GO:0004521)RNA endonuclease activity (GO:0004521)RNA endonuclease activity (GO:0004521)RNA polymerase II transcription initiation surveillance (GO:0160240)RNA polymerase II transcription initiation surveillance (GO:0160240)blood microparticle (GO:0072562)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)integrator complex (GO:0032039)integrator complex (GO:0032039)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein binding (GO:0005515)regulation of transcription elongation by RNA polymerase II (GO:0034243)regulation of transcription elongation by RNA polymerase II (GO:0034243)snRNA 3'-end processing (GO:0034472)snRNA processing (GO:0016180)snRNA processing (GO:0016180)snRNA processing (GO:0016180)

Expression (TPM)

TFs regulating INTS11 0 TFs

Transcription factors with Perturb-seq knockdown data for INTS11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to INTS11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:1,032,438–1,034,753	291.4 kb	Distal (>10kb) Multiome	475
chr1:1,040,071–1,041,597	283.7 kb	Distal (>10kb) Multiome	410
chr1:1,058,856–1,060,114	265.1 kb	Distal (>10kb) Multiome	609
chr1:1,068,556–1,069,991	255.4 kb	Distal (>10kb) Multiome	577
chr1:1,079,478–1,080,558	244.6 kb	Distal (>10kb) Multiome	746
chr1:1,115,769–1,117,022	208.4 kb	Distal (>10kb) Multiome	743
chr1:1,157,424–1,158,362	167.1 kb	Distal (>10kb) Multiome	575
chr1:1,200,907–1,201,739	123.2 kb	Distal (>10kb) Multiome	430
chr1:1,231,448–1,233,390	92.5 kb	Distal (>10kb) Multiome	884
chr1:1,273,333–1,274,645	50.7 kb	Distal (>10kb) Multiome	779
chr1:1,293,434–1,294,454	30.8 kb	Distal (>10kb) Multiome	234
chr1:1,307,375–1,310,219	16.3 kb	Distal (>10kb) Multiome	897
chr1:1,324,278–1,325,394	125 bp	At TSS Multiome	735
chr1:1,348,716–1,350,027	24.9 kb	Distal (>10kb) Multiome	539
chr1:1,353,403–1,354,425	29.2 kb	Distal (>10kb) Multiome	276
chr1:1,374,767–1,375,798	50.7 kb	Distal (>10kb) Multiome	1113
chr1:1,398,861–1,399,955	74.8 kb	Distal (>10kb) Multiome	879
chr1:1,406,992–1,407,823	82.7 kb	Distal (>10kb) Multiome	938
chr1:1,435,318–1,436,066	111.0 kb	Distal (>10kb) Multiome	511
chr1:1,511,442–1,512,404	187.4 kb	Distal (>10kb) Multiome	897
chr1:1,540,164–1,541,317	216.0 kb	Distal (>10kb) Multiome	195
chr1:1,573,904–1,575,432	250.1 kb	Distal (>10kb) Multiome	949
chr1:1,599,945–1,600,642	275.3 kb	Distal (>10kb) Multiome	307
chr1:1,615,103–1,616,799	290.9 kb	Distal (>10kb) Multiome	951

Genome Browser

Genomic view of the INTS11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.