INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for INTS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:1,235,892–1,237,020 | 267.9 kb | Distal (>10kb) Multiome | 184 | |
| chr7:1,368,617–1,369,820 | 135.1 kb | Distal (>10kb) Multiome | 421 | |
| chr7:1,412,524–1,413,381 | 91.4 kb | Distal (>10kb) Multiome | 526 | |
| chr7:1,458,555–1,460,310 | 44.7 kb | Distal (>10kb) Multiome | 677 | |
| chr7:1,474,095–1,474,546 | 30.2 kb | Distal (>10kb) Multiome | 567 | |
| chr7:1,504,094–1,504,782 | 88 bp | At TSS Multiome | 836 | |
| chr7:1,530,385–1,531,336 | 26.3 kb | Distal (>10kb) Multiome | 485 | |
| chr7:1,569,754–1,570,643 | 65.7 kb | Distal (>10kb) Multiome | 876 | |
| chr7:1,664,253–1,667,065 | 160.4 kb | Distal (>10kb) Multiome | 448 | |
| chr7:1,669,081–1,670,862 | 165.7 kb | Distal (>10kb) Multiome | 294 | |
| chr7:1,713,441–1,714,084 | 209.4 kb | Distal (>10kb) Multiome | 662 |
Genomic view of the INTS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.