Predicted to enable inositol trisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in negative regulation of microtubule polymerization. Predicted to act upstream of or within negative regulation of neuron projection development and negative regulation of peptidyl-serine phosphorylation. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for INPP5J. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INPP5J upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INPP5J, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,968,406–30,969,906 | 153.9 kb | Distal (>10kb) Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 41.8 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 37.8 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 24.0 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 17.9 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 15.3 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 4.6 kb | Proximal (<10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 17.6 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 37.3 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 89.2 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 167.9 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,345,143–31,347,910 | 223.1 kb | Distal (>10kb) Multiome | 954 | |
| chr22:31,399,166–31,400,036 | 276.5 kb | Distal (>10kb) Multiome | 913 |
Genomic view of the INPP5J locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.