This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for INPP5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INPP5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INPP5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:37,634,598–37,635,064 | 296.9 kb | Distal (>10kb) Multiome | 192 | |
| chr1:37,663,328–37,663,865 | 268.1 kb | Distal (>10kb) Multiome | 44 | |
| chr1:37,690,078–37,690,919 | 241.2 kb | Distal (>10kb) Multiome | 679 | |
| chr1:37,691,459–37,692,843 | 239.4 kb | Distal (>10kb) Multiome | 781 | |
| chr1:37,752,766–37,753,277 | 178.7 kb | Distal (>10kb) Multiome | 223 | |
| chr1:37,793,768–37,794,528 | 137.6 kb | Distal (>10kb) Multiome | 567 | |
| chr1:37,807,583–37,809,057 | 123.5 kb | Distal (>10kb) Multiome | 755 | |
| chr1:37,859,081–37,860,381 | 72.0 kb | Distal (>10kb) Multiome | 939 | |
| chr1:37,931,446–37,932,215 | 120 bp | At TSS Multiome | 559 | |
| chr1:37,946,605–37,947,220 | 15.3 kb | Distal (>10kb) Multiome | 610 | |
| chr1:37,989,644–37,990,549 | 58.4 kb | Distal (>10kb) Multiome | 1133 | |
| chr1:37,995,790–37,996,610 | 64.4 kb | Distal (>10kb) Multiome | 313 | |
| chr1:38,004,771–38,006,024 | 73.8 kb | Distal (>10kb) Multiome | 442 | |
| chr1:38,012,220–38,013,284 | 80.9 kb | Distal (>10kb) Multiome | 1074 | |
| chr1:38,030,338–38,030,974 | 98.8 kb | Distal (>10kb) Multiome | 225 | |
| chr1:38,045,344–38,048,035 | 115.2 kb | Distal (>10kb) Multiome | 542 | |
| chr1:38,817,720–38,818,696 | 886.5 kb | Distal (>10kb) Multiome HiCAR | 375 |
Genomic view of the INPP5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.