Transcription factors with Perturb-seq knockdown data for INHBA-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INHBA-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INHBA-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:41,696,268–41,696,933 | 8.7 kb | Proximal (<10kb) | 249 | |
| chr7:41,699,601–41,699,869 | 5.7 kb | Proximal (<10kb) | 83 | |
| chr7:41,700,567–41,701,018 | 4.6 kb | Proximal (<10kb) | 100 | |
| chr7:41,701,195–41,701,677 | 3.9 kb | Proximal (<10kb) | 85 | |
| chr7:41,704,846–41,706,204 | at TSS | At TSS | 524 | |
| chr7:41,711,367–41,712,011 | 5.8 kb | Proximal (<10kb) | 124 |
Genomic view of the INHBA-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.