This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ING4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ING4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ING4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,363,292–6,364,138 | 299.6 kb | Distal (>10kb) Multiome | 718 | |
| chr12:6,370,899–6,371,535 | 291.8 kb | Distal (>10kb) Multiome | 572 | |
| chr12:6,375,204–6,377,302 | 287.6 kb | Distal (>10kb) Multiome | 601 | |
| chr12:6,383,790–6,384,442 | 279.0 kb | Distal (>10kb) Multiome | 812 | |
| chr12:6,451,305–6,451,838 | 211.7 kb | Distal (>10kb) Multiome | 535 | |
| chr12:6,469,922–6,471,399 | 192.3 kb | Distal (>10kb) Multiome | 930 | |
| chr12:6,492,998–6,494,331 | 169.8 kb | Distal (>10kb) Multiome | 936 | |
| chr12:6,533,253–6,535,726 | 128.8 kb | Distal (>10kb) Multiome | 1131 | |
| chr12:6,539,914–6,540,883 | 122.4 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 108.8 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 107.0 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 94.8 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 55.6 kb | Distal (>10kb) Multiome | 774 | |
| chr12:6,613,155–6,614,551 | 49.0 kb | Distal (>10kb) Multiome | 810 | |
| chr12:6,620,128–6,620,868 | 42.6 kb | Distal (>10kb) Multiome | 239 | |
| chr12:6,662,802–6,663,663 | 118 bp | At TSS Multiome | 868 | |
| chr12:6,688,517–6,690,027 | 26.3 kb | Distal (>10kb) Multiome HiCAR | 943 | |
| chr12:6,699,959–6,700,887 | 37.3 kb | Distal (>10kb) Multiome | 263 | |
| chr12:6,723,658–6,724,773 | 61.0 kb | Distal (>10kb) Multiome | 1065 | |
| chr12:6,752,554–6,754,332 | 90.4 kb | Distal (>10kb) Multiome | 975 | |
| chr12:6,763,677–6,764,983 | 101.3 kb | Distal (>10kb) Multiome | 570 | |
| chr12:6,765,172–6,767,791 | 103.2 kb | Distal (>10kb) Multiome | 824 | |
| chr12:6,768,329–6,769,331 | 106.0 kb | Distal (>10kb) Multiome | 249 | |
| chr12:6,778,736–6,779,459 | 115.9 kb | Distal (>10kb) Multiome | 777 | |
| chr12:6,821,268–6,822,155 | 158.6 kb | Distal (>10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 162.6 kb | Distal (>10kb) Multiome | 404 | |
| chr12:6,828,101–6,829,966 | 166.5 kb | Distal (>10kb) Multiome | 689 | |
| chr12:6,851,017–6,853,279 | 189.2 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 204.4 kb | Distal (>10kb) Multiome | 887 | |
| chr12:6,871,062–6,874,199 | 209.2 kb | Distal (>10kb) Multiome | 947 | |
| chr12:6,890,735–6,891,820 | 228.1 kb | Distal (>10kb) Multiome | 908 | |
| chr12:6,904,217–6,905,282 | 241.7 kb | Distal (>10kb) Multiome | 566 | |
| chr12:6,914,274–6,914,898 | 251.3 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,924,156–6,924,592 | 261.4 kb | Distal (>10kb) Multiome | 458 | |
| chr12:6,925,828–6,926,431 | 262.9 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,927,411–6,928,051 | 264.7 kb | Distal (>10kb) Multiome | 493 | |
| chr12:6,936,709–6,938,342 | 274.9 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:6,942,356–6,945,492 | 281.1 kb | Distal (>10kb) Multiome | 1205 | |
| chr12:6,945,587–6,947,099 | 283.3 kb | Distal (>10kb) Multiome | 618 | |
| chr12:6,961,769–6,963,542 | 300.1 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the ING4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.