Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for INA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,192,518–103,193,861 | 83.9 kb | Distal (>10kb) Multiome | 725 | |
| chr10:103,204,930–103,206,025 | 72.1 kb | Distal (>10kb) Multiome | 207 | |
| chr10:103,276,757–103,278,251 | 29 bp | At TSS Multiome | 385 | |
| chr10:103,281,678–103,282,102 | 4.5 kb | Proximal (<10kb) | 196 | |
| chr10:103,350,520–103,351,294 | 73.9 kb | Distal (>10kb) Multiome | 679 | |
| chr10:103,367,765–103,368,860 | 91.5 kb | Distal (>10kb) Multiome | 925 | |
| chr10:103,395,952–103,396,926 | 119.4 kb | Distal (>10kb) Multiome | 821 | |
| chr10:103,493,310–103,494,526 | 216.5 kb | Distal (>10kb) Multiome | 299 | |
| chr10:103,542,810–103,543,379 | 265.9 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the INA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.