The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for IMPG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMPG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMPG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,255,263–101,256,022 | 64.9 kb | Distal (>10kb) Multiome | 116 | |
| chr3:101,319,573–101,319,807 | 767 bp | At TSS | 18 | |
| chr3:101,466,683–101,467,491 | 146.6 kb | Distal (>10kb) Multiome | 289 | |
| chr3:101,512,475–101,513,632 | 192.5 kb | Distal (>10kb) Multiome | 799 | |
| chr3:101,530,192–101,530,904 | 210.0 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,561,343–101,562,162 | 241.3 kb | Distal (>10kb) Multiome | 783 | |
| chr3:101,573,305–101,575,121 | 253.5 kb | Distal (>10kb) Multiome | 1039 |
Genomic view of the IMPG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.