This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for IMPA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMPA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMPA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:11,688,830–11,690,282 | 292.1 kb | Distal (>10kb) Multiome | 759 | |
| chr18:11,714,339–11,714,936 | 267.0 kb | Distal (>10kb) Multiome | 121 | |
| chr18:11,751,239–11,752,922 | 229.9 kb | Distal (>10kb) Multiome | 189 | |
| chr18:11,823,081–11,823,838 | 157.9 kb | Distal (>10kb) Multiome | 76 | |
| chr18:11,850,966–11,851,799 | 130.1 kb | Distal (>10kb) Multiome | 890 | |
| chr18:11,908,184–11,909,142 | 73.0 kb | Distal (>10kb) Multiome | 805 | |
| chr18:11,947,210–11,948,156 | 33.9 kb | Distal (>10kb) Multiome | 645 | |
| chr18:11,980,290–11,982,581 | 306 bp | At TSS Multiome | 1002 | |
| chr18:11,983,665–11,983,805 | 2.2 kb | Proximal (<10kb) | 158 | |
| chr18:12,038,383–12,039,391 | 57.6 kb | Distal (>10kb) Multiome | 700 | |
| chr18:12,076,413–12,076,882 | 95.2 kb | Distal (>10kb) Multiome | 129 | |
| chr18:12,253,776–12,254,799 | 272.8 kb | Distal (>10kb) Multiome | 162 | |
| chr18:12,271,329–12,272,193 | 290.4 kb | Distal (>10kb) Multiome | 601 |
Genomic view of the IMPA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.