This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IMP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:75,346,877–75,348,733 | 292.8 kb | Distal (>10kb) Multiome | 738 | |
| chr15:75,367,625–75,369,002 | 272.1 kb | Distal (>10kb) Multiome HiCAR | 1121 | |
| chr15:75,450,273–75,456,388 | 184.3 kb | Distal (>10kb) Multiome HiCAR | 1174 | |
| chr15:75,579,138–75,580,015 | 60.7 kb | Distal (>10kb) Multiome | 683 | |
| chr15:75,624,816–75,626,356 | 14.5 kb | Distal (>10kb) Multiome | 987 | |
| chr15:75,637,487–75,637,811 | 2.4 kb | Proximal (<10kb) | 55 | |
| chr15:75,639,562–75,640,798 | 111 bp | At TSS Multiome | 999 | |
| chr15:75,647,017–75,648,674 | 7.6 kb | Proximal (<10kb) Multiome | 795 | |
| chr15:75,672,794–75,673,400 | 32.8 kb | Distal (>10kb) Multiome | 226 | |
| chr15:75,712,716–75,713,248 | 72.7 kb | Distal (>10kb) Multiome | 318 | |
| chr15:75,738,177–75,739,332 | 98.5 kb | Distal (>10kb) Multiome | 611 | |
| chr15:75,758,383–75,758,865 | 118.3 kb | Distal (>10kb) Multiome | 550 | |
| chr15:75,823,901–75,824,543 | 183.9 kb | Distal (>10kb) Multiome | 98 | |
| chr15:75,842,738–75,844,503 | 203.0 kb | Distal (>10kb) Multiome | 842 | |
| chr15:75,903,363–75,904,635 | 263.7 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the IMP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.