The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ILKAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ILKAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ILKAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:237,966,278–237,967,676 | 236.8 kb | Distal (>10kb) Multiome | 861 | |
| chr2:238,060,279–238,061,878 | 142.8 kb | Distal (>10kb) Multiome | 970 | |
| chr2:238,098,121–238,098,760 | 105.1 kb | Distal (>10kb) Multiome | 222 | |
| chr2:238,158,343–238,159,417 | 44.8 kb | Distal (>10kb) Multiome | 343 | |
| chr2:238,203,020–238,204,239 | 35 bp | At TSS Multiome | 702 | |
| chr2:238,234,336–238,234,816 | 30.8 kb | Distal (>10kb) Multiome | 543 | |
| chr2:238,238,732–238,241,847 | 36.4 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:238,287,738–238,289,462 | 85.3 kb | Distal (>10kb) Multiome | 893 | |
| chr2:238,289,660–238,290,518 | 86.7 kb | Distal (>10kb) Multiome | 315 | |
| chr2:238,319,822–238,321,188 | 116.7 kb | Distal (>10kb) Multiome | 623 | |
| chr2:238,425,866–238,427,628 | 223.2 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the ILKAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.