In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IL27RA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IL27RA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IL27RA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:13,747,559–13,748,233 | 283.9 kb | Distal (>10kb) Multiome | 785 | |
| chr19:13,774,293–13,775,050 | 257.2 kb | Distal (>10kb) Multiome | 904 | |
| chr19:13,794,728–13,795,999 | 236.5 kb | Distal (>10kb) Multiome | 763 | |
| chr19:13,817,290–13,818,525 | 213.8 kb | Distal (>10kb) Multiome | 368 | |
| chr19:13,833,328–13,834,074 | 198.0 kb | Distal (>10kb) Multiome | 638 | |
| chr19:13,841,592–13,843,282 | 188.9 kb | Distal (>10kb) Multiome | 600 | |
| chr19:13,846,368–13,848,126 | 184.0 kb | Distal (>10kb) Multiome | 1040 | |
| chr19:13,850,226–13,850,701 | 181.2 kb | Distal (>10kb) Multiome | 516 | |
| chr19:13,861,855–13,862,533 | 169.4 kb | Distal (>10kb) Multiome | 655 | |
| chr19:13,872,706–13,873,325 | 158.7 kb | Distal (>10kb) Multiome | 254 | |
| chr19:13,879,942–13,880,779 | 151.5 kb | Distal (>10kb) Multiome HiCAR | 780 | |
| chr19:13,905,895–13,906,734 | 125.6 kb | Distal (>10kb) Multiome | 835 | |
| chr19:13,951,898–13,953,117 | 79.4 kb | Distal (>10kb) Multiome | 667 | |
| chr19:13,962,408–13,964,055 | 68.0 kb | Distal (>10kb) Multiome | 166 | |
| chr19:13,978,193–13,979,385 | 53.1 kb | Distal (>10kb) Multiome | 238 | |
| chr19:14,005,474–14,007,363 | 25.2 kb | Distal (>10kb) Multiome | 1098 | |
| chr19:14,031,574–14,032,483 | 398 bp | At TSS Multiome | 726 | |
| chr19:14,057,383–14,057,841 | 25.9 kb | Distal (>10kb) Multiome | 244 | |
| chr19:14,071,936–14,072,417 | 40.5 kb | Distal (>10kb) Multiome | 676 | |
| chr19:14,072,991–14,073,911 | 41.9 kb | Distal (>10kb) Multiome | 589 | |
| chr19:14,081,022–14,082,024 | 49.7 kb | Distal (>10kb) Multiome | 806 | |
| chr19:14,089,535–14,092,049 | 59.3 kb | Distal (>10kb) Multiome | 766 | |
| chr19:14,117,519–14,118,617 | 86.2 kb | Distal (>10kb) Multiome | 734 | |
| chr19:14,136,079–14,137,770 | 105.1 kb | Distal (>10kb) Multiome | 978 | |
| chr19:14,206,623–14,207,699 | 175.4 kb | Distal (>10kb) Multiome | 444 | |
| chr19:14,247,378–14,248,008 | 215.9 kb | Distal (>10kb) Multiome | 109 | |
| chr19:14,248,166–14,249,635 | 217.0 kb | Distal (>10kb) Multiome | 230 | |
| chr19:14,264,813–14,266,130 | 233.7 kb | Distal (>10kb) Multiome | 223 | |
| chr19:14,294,831–14,295,420 | 263.4 kb | Distal (>10kb) Multiome | 60 |
Genomic view of the IL27RA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.