The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for IL12RB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IL12RB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IL12RB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:67,053,062–67,054,800 | 254.2 kb | Distal (>10kb) Multiome | 993 | |
| chr1:67,298,634–67,299,057 | 8.8 kb | Proximal (<10kb) | 52 | |
| chr1:67,307,261–67,308,556 | 112 bp | At TSS Multiome | 323 | |
| chr1:67,429,433–67,431,336 | 122.7 kb | Distal (>10kb) Multiome | 1000 | |
| chr1:67,458,750–67,459,497 | 151.2 kb | Distal (>10kb) Multiome | 199 | |
| chr1:67,500,441–67,500,998 | 192.8 kb | Distal (>10kb) Multiome | 516 | |
| chr1:67,515,399–67,516,305 | 208.0 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the IL12RB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.