The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IL10RB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IL10RB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IL10RB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,025,114–33,026,163 | 240.7 kb | Distal (>10kb) Multiome | 320 | |
| chr21:33,027,208–33,027,934 | 238.7 kb | Distal (>10kb) Multiome | 107 | |
| chr21:33,069,909–33,071,244 | 196.2 kb | Distal (>10kb) Multiome | 330 | |
| chr21:33,229,605–33,230,926 | 36.4 kb | Distal (>10kb) Multiome | 722 | |
| chr21:33,266,016–33,266,841 | 22 bp | At TSS Multiome | 604 | |
| chr21:33,324,272–33,325,694 | 58.5 kb | Distal (>10kb) Multiome | 1015 | |
| chr21:33,402,567–33,402,985 | 136.5 kb | Distal (>10kb) Multiome | 218 | |
| chr21:33,403,116–33,404,351 | 137.0 kb | Distal (>10kb) Multiome | 570 | |
| chr21:33,478,861–33,480,615 | 213.7 kb | Distal (>10kb) Multiome | 839 | |
| chr21:33,491,033–33,492,145 | 225.3 kb | Distal (>10kb) Multiome | 740 | |
| chr21:33,541,871–33,543,585 | 275.6 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the IL10RB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.