Predicted to be involved in response to X-ray. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; response to interleukin-1; and response to tumor necrosis factor. Located in endoplasmic reticulum and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IKBIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IKBIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IKBIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:98,344,774–98,345,967 | 299.4 kb | Distal (>10kb) Multiome | 190 | |
| chr12:98,397,273–98,398,042 | 247.2 kb | Distal (>10kb) Multiome | 455 | |
| chr12:98,456,620–98,457,422 | 187.7 kb | Distal (>10kb) Multiome | 319 | |
| chr12:98,490,969–98,491,482 | 153.6 kb | Distal (>10kb) Multiome | 594 | |
| chr12:98,492,249–98,493,469 | 151.8 kb | Distal (>10kb) Multiome | 235 | |
| chr12:98,502,866–98,504,417 | 141.0 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:98,515,010–98,516,657 | 129.3 kb | Distal (>10kb) Multiome | 999 | |
| chr12:98,593,166–98,594,492 | 51.2 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr12:98,644,115–98,645,908 | 257 bp | At TSS Multiome | 906 | |
| chr12:98,696,171–98,696,840 | 51.7 kb | Distal (>10kb) Multiome | 204 | |
| chr12:98,735,936–98,737,224 | 92.2 kb | Distal (>10kb) Multiome | 226 | |
| chr12:98,894,427–98,895,740 | 250.3 kb | Distal (>10kb) Multiome | 362 | |
| chr12:98,938,452–98,939,645 | 294.1 kb | Distal (>10kb) Multiome | 108 |
Genomic view of the IKBIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.