This gene encodes a conserved proline-rich protein that is a component of the intraflagellar transport-B (IFT-B) core complex. The encoded protein is essential for the integrity of the IFT-B core complex, and for biosynthesis and maintenance of cilia. Mutations in this gene are associated with ciliopathy that affects the skeleton. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for IFT52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:43,457,127–43,458,915 | 133.3 kb | Distal (>10kb) Multiome | 1116 | |
| chr20:43,507,189–43,508,028 | 83.3 kb | Distal (>10kb) Multiome | 658 | |
| chr20:43,508,294–43,509,032 | 82.1 kb | Distal (>10kb) Multiome | 227 | |
| chr20:43,513,723–43,515,130 | 76.7 kb | Distal (>10kb) Multiome | 700 | |
| chr20:43,590,411–43,591,331 | 138 bp | At TSS Multiome | 897 | |
| chr20:43,657,233–43,658,086 | 66.6 kb | Distal (>10kb) Multiome | 995 | |
| chr20:43,666,536–43,667,856 | 76.0 kb | Distal (>10kb) Multiome | 852 | |
| chr20:43,732,772–43,733,261 | 142.1 kb | Distal (>10kb) Multiome | 21 |
Genomic view of the IFT52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.