Predicted to be involved in cilium assembly; intraciliary transport; and protein stabilization. Predicted to act upstream of or within smoothened signaling pathway. Located in cytoplasm. Part of intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IFT46. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT46 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT46, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,359,034–118,359,890 | 206.5 kb | Distal (>10kb) Multiome | 779 | |
| chr11:118,401,086–118,402,051 | 164.5 kb | Distal (>10kb) Multiome | 732 | |
| chr11:118,434,505–118,437,761 | 129.8 kb | Distal (>10kb) Multiome | 1053 | |
| chr11:118,530,432–118,531,848 | 34.9 kb | Distal (>10kb) Multiome | 763 | |
| chr11:118,565,807–118,566,209 | at TSS | At TSS | 563 | |
| chr11:118,571,906–118,572,919 | 6.4 kb | Proximal (<10kb) Multiome | 760 | |
| chr11:118,610,391–118,611,672 | 45.2 kb | Distal (>10kb) Multiome | 488 | |
| chr11:118,620,694–118,621,880 | 55.3 kb | Distal (>10kb) Multiome | 683 | |
| chr11:118,634,418–118,635,567 | 69.0 kb | Distal (>10kb) Multiome | 475 | |
| chr11:118,659,166–118,660,029 | 93.6 kb | Distal (>10kb) Multiome | 459 | |
| chr11:118,689,268–118,690,813 | 124.1 kb | Distal (>10kb) Multiome | 804 | |
| chr11:118,714,768–118,715,435 | 148.8 kb | Distal (>10kb) Multiome | 87 | |
| chr11:118,715,577–118,717,605 | 151.2 kb | Distal (>10kb) Multiome | 445 | |
| chr11:118,789,603–118,790,362 | 223.8 kb | Distal (>10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 226.9 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the IFT46 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.