This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for IFT140. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT140 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT140, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,331,603–1,332,817 | 280.1 kb | Distal (>10kb) Multiome | 492 | |
| chr16:1,333,312–1,334,056 | 278.5 kb | Distal (>10kb) Multiome | 271 | |
| chr16:1,342,604–1,343,805 | 268.9 kb | Distal (>10kb) Multiome | 560 | |
| chr16:1,351,418–1,352,242 | 260.2 kb | Distal (>10kb) Multiome | 733 | |
| chr16:1,378,844–1,380,439 | 232.3 kb | Distal (>10kb) Multiome | 782 | |
| chr16:1,408,010–1,408,819 | 203.7 kb | Distal (>10kb) Multiome | 546 | |
| chr16:1,413,643–1,415,278 | 197.3 kb | Distal (>10kb) Multiome | 661 | |
| chr16:1,420,269–1,421,402 | 191.2 kb | Distal (>10kb) Multiome | 897 | |
| chr16:1,474,566–1,475,411 | 137.0 kb | Distal (>10kb) Multiome | 915 | |
| chr16:1,492,797–1,493,962 | 118.8 kb | Distal (>10kb) Multiome | 710 | |
| chr16:1,610,035–1,611,264 | 1.4 kb | Proximal (<10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 154 bp | At TSS Multiome | 718 | |
| chr16:1,614,100–1,614,386 | 3.4 kb | Proximal (<10kb) | 122 | |
| chr16:1,677,899–1,679,024 | 66.1 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 94.0 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 151.9 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 159.5 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 161.3 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 170.7 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 214.8 kb | Distal (>10kb) Multiome | 1006 |
Genomic view of the IFT140 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.