The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for IFNAR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFNAR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFNAR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,025,114–33,026,163 | 299.3 kb | Distal (>10kb) Multiome | 320 | |
| chr21:33,027,208–33,027,934 | 297.3 kb | Distal (>10kb) Multiome | 107 | |
| chr21:33,069,909–33,071,244 | 254.8 kb | Distal (>10kb) Multiome | 330 | |
| chr21:33,229,605–33,230,926 | 95.1 kb | Distal (>10kb) Multiome | 722 | |
| chr21:33,266,016–33,266,841 | 58.6 kb | Distal (>10kb) Multiome | 604 | |
| chr21:33,324,272–33,325,694 | 141 bp | At TSS Multiome | 1015 | |
| chr21:33,402,567–33,402,985 | 77.9 kb | Distal (>10kb) Multiome | 218 | |
| chr21:33,403,116–33,404,351 | 78.4 kb | Distal (>10kb) Multiome | 570 | |
| chr21:33,478,861–33,480,615 | 155.1 kb | Distal (>10kb) Multiome | 839 | |
| chr21:33,491,033–33,492,145 | 166.6 kb | Distal (>10kb) Multiome | 740 | |
| chr21:33,541,871–33,543,585 | 217.0 kb | Distal (>10kb) Multiome | 996 | |
| chr21:33,587,947–33,589,340 | 263.8 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the IFNAR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.