Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
Transcription factors with Perturb-seq knockdown data for IFITM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFITM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFITM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:206,950–208,051 | 100.6 kb | Distal (>10kb) Multiome | 884 | |
| chr11:208,471–209,205 | 99.3 kb | Distal (>10kb) Multiome | 593 | |
| chr11:235,864–237,255 | 71.6 kb | Distal (>10kb) Multiome | 874 | |
| chr11:288,466–289,320 | 19.1 kb | Distal (>10kb) Multiome | 400 | |
| chr11:313,383–314,476 | 5.8 kb | Proximal (<10kb) Multiome | 421 | |
| chr11:316,978–318,064 | 9.1 kb | Proximal (<10kb) Multiome | 100 | |
| chr11:333,722–334,610 | 26.1 kb | Distal (>10kb) Multiome | 238 | |
| chr11:355,654–356,479 | 48.1 kb | Distal (>10kb) Multiome | 894 | |
| chr11:370,037–370,556 | 62.1 kb | Distal (>10kb) Multiome | 205 | |
| chr11:406,008–408,661 | 99.1 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 109.2 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 140.1 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 142.1 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 199.0 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 227.6 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 229.4 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 247.1 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 252.7 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 260.5 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 268.0 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the IFITM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.