Enables RNA binding activity. Involved in antiviral innate immune response and positive regulation of apoptotic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IFIT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFIT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFIT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:89,224,655–89,225,951 | 59.8 kb | Distal (>10kb) Multiome | 266 | |
| chr10:89,251,129–89,252,212 | 33.1 kb | Distal (>10kb) Multiome | 665 | |
| chr10:89,260,204–89,260,902 | 24.4 kb | Distal (>10kb) Multiome | 392 | |
| chr10:89,278,291–89,278,578 | 6.4 kb | Proximal (<10kb) | 266 | |
| chr10:89,283,791–89,284,485 | 526 bp | At TSS | 206 | |
| chr10:89,284,609–89,285,286 | at TSS | At TSS | 95 | |
| chr10:89,333,420–89,334,413 | 49.2 kb | Distal (>10kb) Multiome | 253 | |
| chr10:89,414,203–89,415,651 | 129.8 kb | Distal (>10kb) Multiome | 735 | |
| chr10:89,535,099–89,536,715 | 250.7 kb | Distal (>10kb) Multiome | 338 |
Genomic view of the IFIT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.