Predicted to enable molecular adaptor activity. Involved in apoptotic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IFI27L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFI27L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFI27L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:93,938,972–93,940,225 | 189.9 kb | Distal (>10kb) Multiome | 431 | |
| chr14:94,026,129–94,026,981 | 103.2 kb | Distal (>10kb) Multiome | 519 | |
| chr14:94,036,395–94,037,000 | 92.9 kb | Distal (>10kb) Multiome | 225 | |
| chr14:94,080,803–94,081,695 | 48.3 kb | Distal (>10kb) Multiome | 679 | |
| chr14:94,129,110–94,129,887 | 23 bp | At TSS Multiome | 322 | |
| chr14:94,136,580–94,137,016 | 7.2 kb | Proximal (<10kb) | 365 | |
| chr14:94,173,317–94,175,546 | 44.6 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the IFI27L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.