This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IER5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IER5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IER5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:180,854,229–180,855,048 | 234.0 kb | Distal (>10kb) Multiome | 299 | |
| chr1:180,911,688–180,913,578 | 175.8 kb | Distal (>10kb) Multiome | 364 | |
| chr1:180,922,741–180,923,870 | 165.4 kb | Distal (>10kb) Multiome | 265 | |
| chr1:180,953,870–180,954,644 | 134.4 kb | Distal (>10kb) Multiome | 386 | |
| chr1:181,021,780–181,023,678 | 65.7 kb | Distal (>10kb) Multiome | 965 | |
| chr1:181,035,921–181,036,673 | 52.4 kb | Distal (>10kb) Multiome | 125 | |
| chr1:181,084,249–181,084,558 | 4.1 kb | Proximal (<10kb) | 360 | |
| chr1:181,088,088–181,090,529 | 61 bp | At TSS Multiome | 1072 | |
| chr1:181,094,976–181,095,188 | 6.3 kb | Proximal (<10kb) | 178 | |
| chr1:181,099,787–181,100,830 | 11.7 kb | Distal (>10kb) Multiome | 413 | |
| chr1:181,101,491–181,102,447 | 13.4 kb | Distal (>10kb) Multiome | 425 | |
| chr1:181,104,541–181,106,069 | 16.7 kb | Distal (>10kb) Multiome | 849 | |
| chr1:181,142,277–181,142,792 | 53.9 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr1:181,152,896–181,153,600 | 64.4 kb | Distal (>10kb) Multiome | 502 | |
| chr1:181,166,371–181,166,866 | 78.0 kb | Distal (>10kb) Multiome | 327 | |
| chr1:181,179,406–181,181,016 | 91.7 kb | Distal (>10kb) Multiome | 389 | |
| chr1:181,189,592–181,190,403 | 101.4 kb | Distal (>10kb) Multiome | 413 | |
| chr1:181,216,477–181,217,204 | 128.2 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the IER5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.