Predicted to enable gluconokinase activity. Predicted to be involved in carbohydrate metabolic process. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IDNK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IDNK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IDNK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,536,923–83,539,150 | 84.5 kb | Distal (>10kb) Multiome | 773 | |
| chr9:83,620,651–83,621,286 | 1.9 kb | Proximal (<10kb) | 347 | |
| chr9:83,622,459–83,623,894 | 16 bp | At TSS Multiome | 774 | |
| chr9:83,630,907–83,631,624 | 8.1 kb | Proximal (<10kb) Multiome | 194 | |
| chr9:83,706,859–83,708,822 | 84.0 kb | Distal (>10kb) Multiome | 1068 | |
| chr9:83,817,135–83,818,401 | 194.7 kb | Distal (>10kb) Multiome | 350 | |
| chr9:83,920,675–83,922,066 | 298.3 kb | Distal (>10kb) Multiome | 895 |
Genomic view of the IDNK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.