This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ICMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ICMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ICMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:5,980,417–5,980,986 | 255.3 kb | Distal (>10kb) Multiome | 282 | |
| chr1:5,991,687–5,993,712 | 243.4 kb | Distal (>10kb) Multiome | 829 | |
| chr1:6,127,538–6,128,516 | 108.0 kb | Distal (>10kb) Multiome | 300 | |
| chr1:6,148,503–6,149,108 | 87.1 kb | Distal (>10kb) Multiome | 254 | |
| chr1:6,199,148–6,200,364 | 36.3 kb | Distal (>10kb) Multiome | 992 | |
| chr1:6,204,893–6,206,690 | 30.7 kb | Distal (>10kb) Multiome | 913 | |
| chr1:6,208,737–6,209,635 | 26.6 kb | Distal (>10kb) Multiome | 362 | |
| chr1:6,235,160–6,236,710 | 53 bp | At TSS Multiome | 673 | |
| chr1:6,238,731–6,239,096 | 2.8 kb | Proximal (<10kb) | 121 | |
| chr1:6,241,773–6,242,771 | 6.3 kb | Proximal (<10kb) Multiome | 241 | |
| chr1:6,244,532–6,247,144 | 10.1 kb | Distal (>10kb) Multiome | 1073 | |
| chr1:6,248,779–6,250,153 | 13.5 kb | Distal (>10kb) Multiome | 287 | |
| chr1:6,259,688–6,261,954 | 24.2 kb | Distal (>10kb) Multiome | 550 | |
| chr1:6,392,724–6,394,325 | 157.6 kb | Distal (>10kb) Multiome | 819 | |
| chr1:6,418,998–6,420,339 | 183.8 kb | Distal (>10kb) Multiome | 335 | |
| chr1:6,440,165–6,441,114 | 204.6 kb | Distal (>10kb) Multiome | 215 | |
| chr1:6,446,981–6,449,427 | 211.2 kb | Distal (>10kb) Multiome | 665 | |
| chr1:6,455,053–6,455,773 | 219.4 kb | Distal (>10kb) Multiome | 105 | |
| chr1:6,470,716–6,471,189 | 234.9 kb | Distal (>10kb) Multiome | 148 | |
| chr1:6,471,308–6,471,972 | 235.6 kb | Distal (>10kb) Multiome | 192 | |
| chr1:6,486,194–6,486,953 | 250.7 kb | Distal (>10kb) Multiome | 416 | |
| chr1:6,489,772–6,491,050 | 254.1 kb | Distal (>10kb) Multiome | 676 | |
| chr1:6,497,162–6,497,841 | 261.5 kb | Distal (>10kb) Multiome | 324 |
Genomic view of the ICMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.