Predicted to enable protein domain specific binding activity. Predicted to be involved in regulation of transport. Predicted to act upstream of or within spermatid development. Predicted to be located in acrosomal vesicle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ICA1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ICA1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ICA1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:202,588,516–202,589,312 | 282.0 kb | Distal (>10kb) Multiome | 565 | |
| chr2:202,634,508–202,636,378 | 236.1 kb | Distal (>10kb) Multiome | 995 | |
| chr2:202,870,773–202,872,210 | 711 bp | At TSS Multiome | 799 | |
| chr2:202,911,342–202,912,577 | 41.2 kb | Distal (>10kb) Multiome | 769 | |
| chr2:203,014,312–203,015,568 | 143.9 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the ICA1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.