This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for ICA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ICA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ICA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:7,566,155–7,567,492 | 695.6 kb | Distal (>10kb) Multiome HiCAR | 741 | |
| chr7:7,968,100–7,970,491 | 293.8 kb | Distal (>10kb) Multiome | 894 | |
| chr7:8,261,188–8,262,737 | 350 bp | At TSS Multiome | 655 | |
| chr7:8,389,706–8,390,552 | 127.5 kb | Distal (>10kb) Multiome | 193 | |
| chr7:8,433,115–8,435,899 | 171.5 kb | Distal (>10kb) Multiome | 645 | |
| chr7:8,441,662–8,444,713 | 180.4 kb | Distal (>10kb) Multiome | 474 |
Genomic view of the ICA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.