The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HTR7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HTR7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HTR7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:89,701,088–89,702,002 | 1156.5 kb | Distal (>10kb) Multiome HiCAR | 944 | |
| chr10:90,856,822–90,858,669 | 179 bp | At TSS Multiome | 536 | |
| chr10:90,871,123–90,872,607 | 13.7 kb | Distal (>10kb) Multiome | 694 | |
| chr10:90,921,025–90,921,678 | 63.3 kb | Distal (>10kb) Multiome | 546 | |
| chr10:90,925,309–90,926,027 | 67.7 kb | Distal (>10kb) Multiome | 268 | |
| chr10:91,050,425–91,051,051 | 192.6 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the HTR7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.