Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HTR1E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HTR1E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HTR1E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:86,481,158–86,481,675 | 456.1 kb | Distal (>10kb) Multiome HiCAR | 146 | |
| chr6:86,936,583–86,938,193 | 218 bp | At TSS Multiome | 406 | |
| chr6:86,943,714–86,944,451 | 6.6 kb | Proximal (<10kb) Multiome | 102 | |
| chr6:87,151,562–87,152,822 | 214.7 kb | Distal (>10kb) Multiome | 359 | |
| chr6:87,154,802–87,156,695 | 217.9 kb | Distal (>10kb) Multiome | 1153 |
Genomic view of the HTR1E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.