Enables protein serine/threonine kinase activity. Involved in import into nucleus and regulation of angiogenesis. Acts upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Located in cytosol and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for HTATIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HTATIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HTATIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:20,131,790–20,132,714 | 231.3 kb | Distal (>10kb) Multiome | 293 | |
| chr11:20,155,773–20,157,362 | 207.1 kb | Distal (>10kb) Multiome | 269 | |
| chr11:20,158,355–20,159,232 | 205.0 kb | Distal (>10kb) Multiome | 241 | |
| chr11:20,162,710–20,164,134 | 200.3 kb | Distal (>10kb) Multiome | 217 | |
| chr11:20,342,395–20,343,383 | 20.8 kb | Distal (>10kb) Multiome | 176 | |
| chr11:20,353,937–20,354,122 | 9.6 kb | Proximal (<10kb) | 139 | |
| chr11:20,355,346–20,355,515 | 8.2 kb | Proximal (<10kb) | 135 | |
| chr11:20,363,378–20,364,674 | 163 bp | At TSS Multiome | 633 | |
| chr11:20,386,914–20,388,428 | 23.8 kb | Distal (>10kb) Multiome | 1064 | |
| chr11:20,522,386–20,523,264 | 159.0 kb | Distal (>10kb) Multiome | 110 | |
| chr11:20,544,392–20,545,572 | 181.1 kb | Distal (>10kb) Multiome | 122 | |
| chr11:20,610,140–20,610,669 | 246.6 kb | Distal (>10kb) Multiome | 413 | |
| chr11:20,631,480–20,632,387 | 268.2 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the HTATIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.