This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for HSPH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:30,865,208–30,865,660 | 296.4 kb | Distal (>10kb) Multiome | 441 | |
| chr13:31,043,982–31,044,684 | 117.5 kb | Distal (>10kb) Multiome | 256 | |
| chr13:31,097,596–31,098,654 | 63.8 kb | Distal (>10kb) Multiome | 71 | |
| chr13:31,160,861–31,162,747 | 275 bp | At TSS Multiome | 924 | |
| chr13:31,199,587–31,200,960 | 38.2 kb | Distal (>10kb) Multiome | 640 |
Genomic view of the HSPH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.