This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for HSPE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:197,309,737–197,311,360 | 189.4 kb | Distal (>10kb) Multiome | 642 | |
| chr2:197,322,642–197,323,971 | 176.8 kb | Distal (>10kb) Multiome | 185 | |
| chr2:197,434,572–197,435,653 | 65.0 kb | Distal (>10kb) Multiome | 937 | |
| chr2:197,452,830–197,454,321 | 46.8 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:197,497,041–197,497,249 | 2.9 kb | Proximal (<10kb) | 28 | |
| chr2:197,498,722–197,500,854 | 47 bp | At TSS Multiome | 1173 | |
| chr2:197,515,482–197,516,752 | 15.9 kb | Distal (>10kb) Multiome | 1138 | |
| chr2:197,586,916–197,587,749 | 87.3 kb | Distal (>10kb) Multiome HiCAR | 118 | |
| chr2:197,704,733–197,706,212 | 205.2 kb | Distal (>10kb) Multiome | 870 | |
| chr2:197,785,007–197,786,878 | 286.1 kb | Distal (>10kb) Multiome | 322 |
Genomic view of the HSPE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.