Enables molecular sequestering activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HSPBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:55,062,536–55,063,406 | 217.2 kb | Distal (>10kb) Multiome | 586 | |
| chr19:55,069,129–55,069,807 | 210.9 kb | Distal (>10kb) Multiome | 288 | |
| chr19:55,080,038–55,082,744 | 198.8 kb | Distal (>10kb) Multiome | 639 | |
| chr19:55,086,246–55,087,525 | 193.2 kb | Distal (>10kb) Multiome | 258 | |
| chr19:55,091,780–55,093,292 | 188.1 kb | Distal (>10kb) Multiome | 208 | |
| chr19:55,095,398–55,095,977 | 184.5 kb | Distal (>10kb) Multiome | 90 | |
| chr19:55,117,134–55,119,109 | 162.7 kb | Distal (>10kb) Multiome | 881 | |
| chr19:55,146,210–55,148,117 | 133.4 kb | Distal (>10kb) Multiome | 528 | |
| chr19:55,156,193–55,157,266 | 123.7 kb | Distal (>10kb) Multiome | 317 | |
| chr19:55,160,567–55,161,360 | 119.6 kb | Distal (>10kb) Multiome | 554 | |
| chr19:55,165,952–55,167,256 | 113.7 kb | Distal (>10kb) Multiome | 719 | |
| chr19:55,173,717–55,174,287 | 106.3 kb | Distal (>10kb) Multiome | 330 | |
| chr19:55,178,876–55,179,477 | 101.3 kb | Distal (>10kb) Multiome | 479 | |
| chr19:55,216,490–55,217,227 | 63.5 kb | Distal (>10kb) Multiome | 1077 | |
| chr19:55,257,751–55,259,635 | 21.2 kb | Distal (>10kb) Multiome | 1054 | |
| chr19:55,279,599–55,280,933 | 108 bp | At TSS Multiome | 805 | |
| chr19:55,283,835–55,284,716 | 3.7 kb | Proximal (<10kb) Multiome | 242 | |
| chr19:55,301,640–55,302,240 | 21.6 kb | Distal (>10kb) Multiome | 448 | |
| chr19:55,338,676–55,340,358 | 59.2 kb | Distal (>10kb) Multiome | 882 | |
| chr19:55,340,675–55,341,535 | 61.0 kb | Distal (>10kb) Multiome | 368 | |
| chr19:55,353,720–55,354,487 | 73.7 kb | Distal (>10kb) Multiome | 297 | |
| chr19:55,369,099–55,370,447 | 89.7 kb | Distal (>10kb) Multiome | 383 | |
| chr19:55,383,539–55,384,553 | 103.5 kb | Distal (>10kb) Multiome | 374 | |
| chr19:55,384,697–55,386,560 | 105.3 kb | Distal (>10kb) Multiome | 903 | |
| chr19:55,406,950–55,408,675 | 127.7 kb | Distal (>10kb) Multiome HiCAR | 965 | |
| chr19:55,452,738–55,453,308 | 172.7 kb | Distal (>10kb) Multiome | 339 | |
| chr19:55,460,784–55,462,230 | 181.4 kb | Distal (>10kb) Multiome | 947 | |
| chr19:55,476,048–55,477,307 | 196.3 kb | Distal (>10kb) Multiome | 1007 | |
| chr19:55,484,846–55,485,682 | 204.8 kb | Distal (>10kb) Multiome | 594 | |
| chr19:55,503,638–55,504,310 | 223.6 kb | Distal (>10kb) Multiome | 710 | |
| chr19:55,516,768–55,517,459 | 236.7 kb | Distal (>10kb) Multiome | 583 | |
| chr19:55,536,923–55,537,366 | 256.8 kb | Distal (>10kb) Multiome | 180 | |
| chr19:55,549,822–55,550,343 | 269.7 kb | Distal (>10kb) Multiome | 396 |
Genomic view of the HSPBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.