This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for HSPBAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPBAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPBAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:122,514,019–122,515,266 | 279.0 kb | Distal (>10kb) Multiome | 888 | |
| chr3:122,564,086–122,564,854 | 229.4 kb | Distal (>10kb) Multiome | 849 | |
| chr3:122,680,509–122,681,348 | 112.8 kb | Distal (>10kb) Multiome | 567 | |
| chr3:122,798,643–122,799,856 | 5.4 kb | Proximal (<10kb) Multiome | 131 | |
| chr3:122,890,181–122,890,667 | 96.5 kb | Distal (>10kb) Multiome | 154 | |
| chr3:122,942,761–122,943,436 | 149.3 kb | Distal (>10kb) Multiome | 336 | |
| chr3:122,975,104–122,975,992 | 181.7 kb | Distal (>10kb) Multiome | 338 | |
| chr3:123,026,031–123,028,771 | 234.0 kb | Distal (>10kb) Multiome | 478 | |
| chr3:123,066,643–123,067,789 | 273.2 kb | Distal (>10kb) Multiome | 865 | |
| chr3:123,080,786–123,081,476 | 287.2 kb | Distal (>10kb) Multiome | 291 | |
| chr3:123,081,598–123,082,265 | 288.3 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the HSPBAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.