Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Located in cytosol and ribosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for HSPA14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPA14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPA14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:14,603,765–14,604,803 | 233.9 kb | Distal (>10kb) Multiome HiCAR | 535 | |
| chr10:14,649,147–14,650,080 | 188.7 kb | Distal (>10kb) Multiome | 36 | |
| chr10:14,737,931–14,738,710 | 100.0 kb | Distal (>10kb) Multiome | 67 | |
| chr10:14,837,437–14,839,368 | 158 bp | At TSS Multiome | 908 | |
| chr10:14,877,852–14,879,824 | 40.4 kb | Distal (>10kb) Multiome | 977 | |
| chr10:14,952,697–14,954,554 | 114.8 kb | Distal (>10kb) Multiome | 1101 | |
| chr10:14,959,013–14,960,243 | 121.2 kb | Distal (>10kb) Multiome | 879 | |
| chr10:15,088,358–15,089,070 | 250.5 kb | Distal (>10kb) Multiome | 622 | |
| chr10:15,096,597–15,098,027 | 258.9 kb | Distal (>10kb) Multiome | 949 |
Genomic view of the HSPA14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.