This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for HSD17B12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:43,576,840–43,577,310 | 103.5 kb | Distal (>10kb) Multiome | 464 | |
| chr11:43,578,930–43,580,292 | 101.3 kb | Distal (>10kb) Multiome | 326 | |
| chr11:43,643,882–43,644,534 | 36.5 kb | Distal (>10kb) Multiome | 809 | |
| chr11:43,680,105–43,681,375 | 64 bp | At TSS Multiome | 774 | |
| chr11:43,688,612–43,688,791 | 7.9 kb | Proximal (<10kb) | 19 | |
| chr11:43,689,266–43,689,658 | 8.6 kb | Proximal (<10kb) | 105 | |
| chr11:43,880,452–43,881,136 | 200.1 kb | Distal (>10kb) Multiome | 939 | |
| chr11:43,942,022–43,943,596 | 261.8 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the HSD17B12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.