Enables chromatin binding activity; histone binding activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in DNA repair-dependent chromatin remodeling and double-strand break repair. Located in chromatin and nucleus. Is active in site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HPF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HPF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HPF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:169,611,998–169,613,442 | 145.3 kb | Distal (>10kb) Multiome | 840 | |
| chr4:169,619,912–169,621,246 | 137.5 kb | Distal (>10kb) Multiome | 896 | |
| chr4:169,757,346–169,758,297 | 14 bp | At TSS Multiome | 724 | |
| chr4:169,774,514–169,775,438 | 17.0 kb | Distal (>10kb) Multiome | 195 | |
| chr4:169,918,815–169,920,220 | 161.9 kb | Distal (>10kb) Multiome | 227 | |
| chr4:169,934,787–169,935,471 | 177.1 kb | Distal (>10kb) Multiome | 121 | |
| chr4:170,004,428–170,005,171 | 246.8 kb | Distal (>10kb) Multiome | 112 | |
| chr4:170,025,638–170,027,809 | 268.5 kb | Distal (>10kb) Multiome | 968 |
Genomic view of the HPF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.