This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for HMGXB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMGXB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMGXB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:149,729,917–149,732,346 | 270.5 kb | Distal (>10kb) Multiome | 829 | |
| chr5:149,960,169–149,961,325 | 40.0 kb | Distal (>10kb) Multiome | 836 | |
| chr5:149,990,859–149,991,061 | 9.7 kb | Proximal (<10kb) | 182 | |
| chr5:149,999,983–150,001,489 | 181 bp | At TSS Multiome | 940 | |
| chr5:150,001,754–150,002,001 | 1.0 kb | Proximal (<10kb) | 248 | |
| chr5:150,130,018–150,131,367 | 130.1 kb | Distal (>10kb) Multiome | 516 | |
| chr5:150,161,225–150,162,105 | 160.9 kb | Distal (>10kb) Multiome | 389 | |
| chr5:150,211,110–150,211,964 | 210.8 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the HMGXB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.