HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HLA-DPB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HLA-DPB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HLA-DPB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,837,981–32,838,977 | 241.7 kb | Distal (>10kb) Multiome | 821 | |
| chr6:32,844,222–32,845,071 | 235.7 kb | Distal (>10kb) Multiome | 534 | |
| chr6:32,853,077–32,854,448 | 226.3 kb | Distal (>10kb) Multiome | 841 | |
| chr6:32,893,822–32,895,230 | 185.8 kb | Distal (>10kb) Multiome | 774 | |
| chr6:32,952,883–32,953,496 | 127.1 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,972–32,971,214 | 111.6 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 108.3 kb | Distal (>10kb) Multiome | 1115 | |
| chr6:33,009,348–33,009,899 | 70.7 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr6:33,080,260–33,080,486 | at TSS | At TSS | 158 | |
| chr6:33,080,635–33,081,087 | 250 bp | At TSS | 141 | |
| chr6:33,161,505–33,162,100 | 81.3 kb | Distal (>10kb) Multiome | 589 | |
| chr6:33,199,801–33,201,289 | 120.2 kb | Distal (>10kb) Multiome | 1049 | |
| chr6:33,204,263–33,205,422 | 124.2 kb | Distal (>10kb) Multiome | 762 | |
| chr6:33,208,069–33,208,990 | 128.2 kb | Distal (>10kb) Multiome | 858 | |
| chr6:33,248,132–33,249,983 | 169.0 kb | Distal (>10kb) Multiome | 961 | |
| chr6:33,271,370–33,272,508 | 191.6 kb | Distal (>10kb) Multiome | 1058 | |
| chr6:33,276,685–33,277,905 | 197.0 kb | Distal (>10kb) Multiome | 807 | |
| chr6:33,288,941–33,289,881 | 209.0 kb | Distal (>10kb) Multiome | 701 | |
| chr6:33,297,445–33,300,232 | 217.5 kb | Distal (>10kb) Multiome | 1095 | |
| chr6:33,312,436–33,314,207 | 232.5 kb | Distal (>10kb) Multiome | 795 | |
| chr6:33,317,189–33,318,504 | 237.5 kb | Distal (>10kb) Multiome | 649 | |
| chr6:33,322,636–33,323,832 | 242.8 kb | Distal (>10kb) Multiome | 941 |
Genomic view of the HLA-DPB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.