Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for HINT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HINT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HINT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:124,961,736–124,963,798 | 994.5 kb | Distal (>10kb) Multiome HiCAR | 660 | |
| chr6:125,301,431–125,302,347 | 654.9 kb | Distal (>10kb) Multiome HiCAR | 1009 | |
| chr6:125,700,629–125,701,546 | 255.7 kb | Distal (>10kb) Multiome | 153 | |
| chr6:125,745,345–125,746,068 | 211.0 kb | Distal (>10kb) Multiome | 210 | |
| chr6:125,746,584–125,747,315 | 209.8 kb | Distal (>10kb) Multiome | 391 | |
| chr6:125,747,542–125,750,482 | 207.2 kb | Distal (>10kb) Multiome | 891 | |
| chr6:125,780,157–125,781,423 | 176.4 kb | Distal (>10kb) Multiome HiCAR | 1022 | |
| chr6:125,789,677–125,791,851 | 166.0 kb | Distal (>10kb) Multiome HiCAR | 1017 | |
| chr6:125,867,468–125,867,998 | 89.0 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr6:125,952,889–125,953,903 | 3.2 kb | Proximal (<10kb) Multiome | 343 | |
| chr6:125,956,540–125,957,527 | 79 bp | At TSS Multiome | 1085 | |
| chr6:125,957,959–125,958,139 | 1.2 kb | Proximal (<10kb) | 159 | |
| chr6:125,963,192–125,963,384 | 6.4 kb | Proximal (<10kb) | 42 | |
| chr6:125,986,066–125,987,257 | 29.7 kb | Distal (>10kb) Multiome | 925 |
Genomic view of the HINT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.