Enables signaling receptor binding activity. Involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Located in several cellular components, including cell surface; lipid droplet; and secretory granule. Implicated in colorectal cancer and hepatocellular carcinoma. Biomarker of colorectal cancer and hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HILPDA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HILPDA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HILPDA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,166,496–128,169,100 | 287.1 kb | Distal (>10kb) Multiome | 559 | |
| chr7:128,200,949–128,201,858 | 254.4 kb | Distal (>10kb) Multiome | 168 | |
| chr7:128,235,091–128,235,888 | 220.3 kb | Distal (>10kb) Multiome | 40 | |
| chr7:128,266,969–128,267,714 | 188.4 kb | Distal (>10kb) Multiome | 395 | |
| chr7:128,298,870–128,299,537 | 156.6 kb | Distal (>10kb) Multiome | 53 | |
| chr7:128,343,565–128,344,079 | 112.0 kb | Distal (>10kb) Multiome | 1136 | |
| chr7:128,350,941–128,352,858 | 103.6 kb | Distal (>10kb) Multiome | 308 | |
| chr7:128,360,334–128,361,049 | 95.1 kb | Distal (>10kb) Multiome | 282 | |
| chr7:128,361,158–128,362,317 | 94.1 kb | Distal (>10kb) Multiome | 459 | |
| chr7:128,381,074–128,381,660 | 74.5 kb | Distal (>10kb) Multiome | 156 | |
| chr7:128,387,606–128,388,141 | 68.0 kb | Distal (>10kb) Multiome | 289 | |
| chr7:128,405,316–128,406,560 | 49.8 kb | Distal (>10kb) Multiome | 559 | |
| chr7:128,409,174–128,410,630 | 45.8 kb | Distal (>10kb) Multiome | 740 | |
| chr7:128,453,519–128,453,932 | 1.9 kb | Proximal (<10kb) | 29 | |
| chr7:128,454,251–128,454,939 | 1.3 kb | Proximal (<10kb) Multiome | 220 | |
| chr7:128,455,301–128,456,353 | 27 bp | At TSS Multiome | 875 | |
| chr7:128,459,404–128,459,602 | 3.6 kb | Proximal (<10kb) | 187 | |
| chr7:128,476,406–128,477,319 | 20.9 kb | Distal (>10kb) Multiome | 616 | |
| chr7:128,530,813–128,532,054 | 75.4 kb | Distal (>10kb) Multiome | 421 | |
| chr7:128,697,256–128,697,860 | 241.7 kb | Distal (>10kb) Multiome | 373 | |
| chr7:128,738,818–128,739,927 | 283.4 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the HILPDA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.