The protein encoded by this gene is a subunit of the cytochrome c oxidase complex (complex IV), which is the terminal enzyme in the mitochondrial respiratory chain. The encoded protein is an inner mitochondrial membrane protein and is a functional ortholog of the yeast respiratory supercomplex factor 1 (Rcf1). In mouse, the orthologous protein enhances cell survival under conditions of hypoxia. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for HIGD2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIGD2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIGD2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,172,154–176,172,641 | 216.2 kb | Distal (>10kb) Multiome | 15 | |
| chr5:176,183,360–176,184,067 | 205.0 kb | Distal (>10kb) Multiome | 165 | |
| chr5:176,361,095–176,362,133 | 27.0 kb | Distal (>10kb) Multiome | 877 | |
| chr5:176,365,184–176,366,532 | 23.2 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,388,019–176,389,614 | 221 bp | At TSS Multiome | 1052 | |
| chr5:176,415,859–176,416,971 | 27.9 kb | Distal (>10kb) Multiome | 827 | |
| chr5:176,441,967–176,442,454 | 53.5 kb | Distal (>10kb) Multiome | 166 | |
| chr5:176,447,162–176,449,016 | 59.5 kb | Distal (>10kb) Multiome | 859 | |
| chr5:176,536,385–176,538,671 | 149.2 kb | Distal (>10kb) Multiome | 1006 | |
| chr5:176,541,333–176,544,229 | 152.9 kb | Distal (>10kb) Multiome | 733 | |
| chr5:176,596,638–176,597,570 | 208.3 kb | Distal (>10kb) Multiome | 234 | |
| chr5:176,609,466–176,610,727 | 221.3 kb | Distal (>10kb) Multiome | 544 | |
| chr5:176,618,956–176,619,934 | 230.6 kb | Distal (>10kb) Multiome | 328 | |
| chr5:176,630,050–176,630,816 | 241.7 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,646,726–176,648,437 | 258.6 kb | Distal (>10kb) Multiome | 701 | |
| chr5:176,660,849–176,661,318 | 272.3 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the HIGD2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.