Predicted to act upstream of or within several processes, including insulin processing; secretory granule maturation; and vacuole fusion, non-autophagic. Located in Golgi apparatus; cytoplasmic microtubule; and cytosol. Implicated in developmental and epileptic encephalopathy 105. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HID1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HID1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HID1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,736,296–74,738,156 | 235.4 kb | Distal (>10kb) Multiome | 797 | |
| chr17:74,744,666–74,745,585 | 227.8 kb | Distal (>10kb) Multiome | 580 | |
| chr17:74,748,109–74,749,683 | 224.2 kb | Distal (>10kb) Multiome | 915 | |
| chr17:74,775,871–74,776,940 | 196.4 kb | Distal (>10kb) Multiome | 798 | |
| chr17:74,842,511–74,843,541 | 129.7 kb | Distal (>10kb) Multiome | 412 | |
| chr17:74,852,259–74,853,211 | 120.1 kb | Distal (>10kb) Multiome | 435 | |
| chr17:74,872,506–74,873,926 | 99.6 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:74,972,019–74,973,116 | 1 bp | At TSS Multiome | 607 | |
| chr17:74,982,006–74,982,936 | 9.6 kb | Proximal (<10kb) Multiome | 952 | |
| chr17:74,987,081–74,988,770 | 14.9 kb | Distal (>10kb) Multiome | 702 | |
| chr17:75,012,158–75,013,285 | 40.0 kb | Distal (>10kb) Multiome | 1058 | |
| chr17:75,033,550–75,035,757 | 61.1 kb | Distal (>10kb) Multiome | 1228 | |
| chr17:75,046,451–75,047,855 | 74.3 kb | Distal (>10kb) Multiome | 961 | |
| chr17:75,087,344–75,088,429 | 115.1 kb | Distal (>10kb) Multiome | 717 | |
| chr17:75,109,401–75,110,734 | 137.2 kb | Distal (>10kb) Multiome | 762 | |
| chr17:75,130,577–75,132,090 | 159.0 kb | Distal (>10kb) Multiome | 990 | |
| chr17:75,153,354–75,155,273 | 181.9 kb | Distal (>10kb) Multiome | 993 | |
| chr17:75,182,199–75,183,441 | 210.3 kb | Distal (>10kb) Multiome | 908 | |
| chr17:75,205,060–75,205,995 | 232.7 kb | Distal (>10kb) Multiome | 975 | |
| chr17:75,240,373–75,240,941 | 267.9 kb | Distal (>10kb) Multiome | 436 | |
| chr17:75,261,304–75,262,404 | 289.0 kb | Distal (>10kb) Multiome | 983 | |
| chr17:75,270,231–75,271,942 | 298.5 kb | Distal (>10kb) Multiome | 946 |
Genomic view of the HID1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.