This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for HIBADH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIBADH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIBADH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:27,235,136–27,236,870 | 427.3 kb | Distal (>10kb) Multiome HiCAR | 402 | |
| chr7:27,239,185–27,240,005 | 423.2 kb | Distal (>10kb) Multiome HiCAR | 169 | |
| chr7:27,448,884–27,449,537 | 213.7 kb | Distal (>10kb) Multiome | 94 | |
| chr7:27,662,196–27,663,278 | 116 bp | At TSS Multiome | 918 | |
| chr7:27,664,276–27,664,533 | 1.4 kb | Proximal (<10kb) | 39 | |
| chr7:27,739,539–27,741,150 | 77.2 kb | Distal (>10kb) Multiome | 940 |
Genomic view of the HIBADH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.