Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HERPUD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HERPUD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HERPUD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:35,537,034–35,537,920 | 157.6 kb | Distal (>10kb) Multiome | 411 | |
| chr7:35,587,467–35,588,810 | 107.1 kb | Distal (>10kb) Multiome | 70 | |
| chr7:35,624,084–35,625,028 | 70.5 kb | Distal (>10kb) Multiome | 320 | |
| chr7:35,647,096–35,647,552 | 47.9 kb | Distal (>10kb) Multiome | 270 | |
| chr7:35,694,331–35,695,753 | 49 bp | At TSS Multiome | 948 | |
| chr7:35,800,074–35,802,134 | 105.8 kb | Distal (>10kb) Multiome | 972 |
Genomic view of the HERPUD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.